Recruiting

Testing an implant to restore central vision in inherited eye disease

Plain-English translation of NCT07266584 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing the PRIMA Products—a special implant designed to help restore limited vision in people with severe sight loss from inherited retinal degeneration (diseases like Stargardt disease and retinitis pigmentosa). The device has already been tested safely and successfully in 38 patients with a different eye condition, and researchers now want to see if it can also help people whose central vision has been lost due to photoreceptor cell degeneration.

Many people with inherited retinal diseases lose their central vision and have no current treatment options. This trial exists to find out whether this treatment can safely restore some useful sight to patients who have exhausted other options.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with inherited retinal degeneration affecting your macula (central vision area) in both eyes
your vision in the study eye is very poor (20/320 or worse on a standard eye chart)
you have an area of vision loss in your eye that includes the fovea (center of vision) and is larger than the implant size
you are willing to attend all scheduled follow-up visits

You likely don't qualify if…

you have an untreated cataract in the study eye (you may qualify after cataract surgery)
you have no light perception in either eye
you have had certain other eye conditions or surgeries, such as a telescope implant in one eye or a history of abnormal blood vessel growth in the retina
you have uncontrolled epileptic seizures or conditions that would prevent you from understanding the study or communicating about it
you have a known allergy to anesthesia or to the materials in the implant (iridium oxide, silicon carbide, or titanium)

What participation looks like

If you qualify, you would undergo surgery to have the implant placed in your eye. Before and after the procedure, you will have multiple eye exams and imaging tests to check how well the treatment is working and to monitor for any side effects. You will need to commit to returning for all scheduled follow-up visits so the research team can evaluate whether the implant is safely restoring any of your central vision.

AI-generated summary from trial data · Jun 15, 2026 · Not medical advice

Trial locations(1 site)

Australia

Sydney Eye Hospital, Sydney, New South Wales