Plain-English translation of NCT07267260 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This clinical trial is testing whether vonoprazan, a medication that reduces stomach acid, can help prevent ulcers that sometimes develop after a procedure called endoscopic variceal band ligation (EVBL). EVBL is used to treat dangerous enlarged veins in the food pipe that can occur in people with liver cirrhosis. The study will compare this medication to a placebo (a dummy pill) to see if the treatment reduces ulcers, pain, and swallowing difficulty after the procedure.
After EVBL, some patients develop painful ulcers in the esophagus and stomach that can cause discomfort or delayed bleeding. Researchers believe that reducing stomach acid with this medication might help protect the tissue and improve recovery after this important liver procedure.
You likely qualify if…
You likely don't qualify if…
After your EVBL procedure, you will take either the study medication or a placebo pill by mouth once daily for 14 days. You will need to return for a follow-up endoscopy (camera examination) about two weeks after your procedure to check for ulcers. During the study, you'll report any symptoms like pain, nausea, or difficulty swallowing to the research team. The entire study takes about two weeks of active participation, plus a follow-up visit.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
Pakistan