New radiation therapy combined with chemotherapy for advanced pancreatic cancer

Plain-English translation of NCT07269626 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new radiation therapy approach called PULSAR (personalized ultrafractionated stereotactic adaptive radiation therapy) combined with standard chemotherapy for pancreatic cancer patients whose disease cannot be surgically removed. PULSAR uses very precise, targeted radiation delivered in a way designed to reduce damage to the healthy organs surrounding the pancreas. The study will see whether this combination of the new radiation technique with chemotherapy can better control the cancer and improve how long patients survive.

Pancreatic cancer is very difficult to treat, especially when it has grown too much to be removed by surgery. While chemotherapy is the standard treatment, local progression of the cancer in the pancreas can cause severe pain and other serious complications. The challenge is that the pancreas sits near sensitive organs like the stomach and small intestine, making it risky to deliver enough radiation to effectively control the tumor. This trial exists to test whether the new PULSAR technique can deliver higher, more effective radiation while being safer for the surrounding organs.

Do you qualify?

You likely qualify if…

you are at least 19 years old and in reasonably good overall health
you have been diagnosed with pancreatic ductal adenocarcinoma that cannot be surgically removed or has spread to three or fewer distant sites
you have already completed 2 to 4 cycles of standard first-line chemotherapy without your cancer getting worse in distant locations
your cancer has not progressed to your brain or spinal cord
you understand the study and are willing to give written consent to participate

You likely don't qualify if…

you are pregnant or breastfeeding
you have brain metastases or disease in the membranes around your spinal cord
you have received prior radiation therapy to the area being considered for treatment
you have serious medical conditions that would make it unsafe to participate, such as uncontrolled infection, heart failure, or severe mental illness
your doctor believes you are unlikely to follow the study procedures or attend required follow-up visits

What participation looks like

If you join this trial, you would continue receiving your standard chemotherapy while also undergoing the new PULSAR radiation therapy. The radiation treatment would be personalized to your specific tumor, delivering high-dose radiation in a shorter timeframe than conventional radiation, which allows you to continue your chemotherapy without long interruptions. You would have regular visits with the study team to monitor how you are responding to treatment and to watch for any side effects.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Trial locations(1 site)

South Korea

Samsung Medical Center, Seoul, Select Province/State

View full record on ClinicalTrials.gov