Plain-English translation of NCT07271420 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Hypertension research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing hydrochlorothiazide, a water pill that helps lower blood pressure, in people who are on peritoneal dialysis (a treatment for kidney failure) and have high blood pressure that isn't well controlled. The study will compare what happens when you take this medication versus when you don't, to see if it can safely and effectively bring your blood pressure down.
People on peritoneal dialysis often struggle with high blood pressure that's hard to control with standard treatments. Researchers want to know if this medication, which works differently than many other blood pressure drugs, could be a helpful addition for this specific group of patients.
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You would take the blood pressure medication once daily for 90 days, along with your other regular dialysis treatments and medications. After a 2-week break, you would then enter a 90-day period without the new medication so researchers can compare the results. Throughout the study, your blood pressure would be monitored to see how well the treatment works.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Hong Kong
Phase
Post-approval monitoring
Sponsor
Chinese University of Hong Kong
Enrollment target
~40 participants
Started
January 2020
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in December 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Gordon Chan, MD, MRCP
Chinese University of Hong Kong
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.