Recruiting

Digital tools to detect early memory changes in older adults

Plain-English translation of NCT07272811 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This study is testing a new digital platform called the Neurocognitive Assessment Platform 4 Alzheimer that uses non-invasive sensors — including brain wave recordings, blood flow monitors, and eye-tracking — to detect early signs of memory loss. Researchers want to identify which people with mild cognitive changes are most likely to develop Alzheimer's disease, so doctors can intervene earlier. The study will follow 100 participants over one year to see which measurements best predict who will progress to dementia.

Current medications for Alzheimer's are not very effective, so researchers believe that catching memory problems early and offering help before full dementia develops could improve outcomes. This study aims to create better tools for early detection so that people can receive support sooner.

Do you qualify?

You likely qualify if…

you are between 55 and 80 years old
you have no significant problems with daily living activities, or only minor difficulties with complex tasks
you are willing to give informed consent and understand the study
if in the memory-decline group: you have noticed memory problems yourself, or family or a doctor has reported them to you
if in the healthy control group: you score 28 or higher on standard memory tests and have no memory or thinking problems unusual for your age

You likely don't qualify if…

you have significant hearing loss or vision problems that would prevent you from using the sensors
you have a current or past history of serious mental illness
you have any previous neurological disease affecting the brain or nervous system
you have a history of stroke or significant brain blood vessel problems
you have a history of heavy alcohol use or regular use of mood-altering medications

What participation looks like

You would visit the study center regularly over 12 months for assessments using the digital platform. During each visit, you would wear non-invasive sensors that measure brain activity, blood flow, and eye movements while completing memory and thinking tests. The visits would take several hours, but the sensors are painless and safe. Researchers will track your results over time to see which measurements best predict who develops memory problems.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(1 site)

Italy

IRCCS San Raffele, Milan, Italy