Plain-English translation of NCT07272837 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 2 Diabetes research guide →Researchers want to understand how semaglutide affects your muscles and heart when you take it for type 2 diabetes or weight loss. The medication is known to help people lose weight, but scientists want to make sure it doesn't cause unhealthy muscle loss along the way. This study uses detailed MRI scans and physical fitness tests to track what happens to your body over 12 months.
When people lose weight quickly, they sometimes lose muscle as well as fat—which can affect strength, balance, and overall health. This medication is very popular, but doctors need to know more about its effects on muscle health, especially for people who might be at higher risk of muscle loss.
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You would visit the research center three times over one year. At each visit, you'll have MRI scans of your heart, belly, and legs (some while you're resting, some while exercising), do simple fitness tests like standing up from a chair and measuring grip strength, answer health questions, give a small blood sample, and write down what you eat for three days. The whole process takes a few hours per visit.
AI-generated summary from trial data · Aug 8, 2026 · Not medical advice
Canada
Enrollment target
~50 participants
Started
May 2026
Primary completion
December 2027
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Krista Jong, RD, BSc
University of Alberta
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.