Recruiting

Testing exercise training to reduce tiredness after stroke

Plain-English translation of NCT07273058 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated June 2026 · How we translate trials

Read our Stroke research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Post-stroke fatigue is extreme tiredness that affects many stroke survivors and can make recovery harder. This trial tests whether two different types of supervised exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—can reduce this fatigue better than stretching alone. The study will track fatigue levels, blood markers of inflammation, and other health measures over 12 weeks to see which approach works best.

Many stroke survivors experience severe fatigue that doesn't improve with standard rehabilitation, and there are no proven treatments specifically for it. This trial aims to discover whether exercise—and which type—can be an effective way to help people recover more energy and quality of life after stroke.

Do you qualify?

You likely qualify if…

you are between 40 and 80 years old
you had an ischemic stroke (caused by a blood clot) between 6 months and 5 years ago that affected one side of your body
you have felt unusually tired or fatigued for at least 2 weeks in the past month
you are medically stable and able to walk at least 10 meters with or without a walking aid
you can communicate clearly and do not have significant memory or thinking problems

You likely don't qualify if…

you have other neurological conditions besides stroke
you have severe heart, lung, or metabolic diseases or had symptoms of these in the past 3 months
you have severe muscle stiffness in your lower limbs from the stroke
you are currently taking or have recently taken medications designed to treat post-stroke fatigue
you are already enrolled in another stroke rehabilitation study

What participation looks like

If you join, you will be randomly assigned to one of three groups: high-intensity interval training, moderate-intensity continuous training, or stretching exercises. You will attend supervised exercise sessions three times per week for 12 weeks (36 total sessions). Your fatigue, blood work, and other health measures will be checked at the start, at 6 weeks, at 12 weeks, and again at 20 weeks to see how you respond to the exercise program.

AI-generated summary from trial data · Jun 25, 2026 · Not medical advice

Trial locations(1 site)

Hong Kong

The Hong Kong Polytechnic University, Kowloon