Plain-English translation of NCT07273188 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn's Disease research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing a new imaging scan called 68Ga-FAPI-46 PET to see if it can detect early scarring and narrowing in the small bowel of people with Crohn's disease. This scan uses a radioactive tracer that attaches to cells involved in scarring, helping doctors see fibrosis at early stages before it becomes a serious stricture (blockage). The goal is to understand how scarring develops so doctors can catch and treat it earlier.
Many people with Crohn's disease develop scarring and strictures (narrow sections) in their small bowel that can cause pain and blockages. Current scans are good at detecting advanced strictures, but this treatment may help doctors spot early scarring before it becomes a problem, potentially allowing for earlier intervention.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will come in for a PET scan using the new 68Ga-FAPI-46 tracer. Researchers will also review your recent CT or MRI scans from your regular care. The study compares people who have strictures (scarring-related blockages) with those who don't, so researchers can understand how the new scan detects scarring at different stages. The main commitment is undergoing the specialized scan; the study is designed to be completed in a relatively short timeframe.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Mayo Clinic
Collaborators
The Leona M. and Harry B. Helmsley Charitable Trust
Enrollment target
~45 participants
Started
January 2026
Primary completion
February 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Brian Will
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.