Better radiation therapy planning for localized prostate cancer

Plain-English translation of NCT07276438 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This trial is testing a new approach to radiation therapy for prostate cancer called stereotactic body radiation therapy (SBRT). The study compares two types of SBRT: one that uses the same treatment plan every day, and one that adjusts the treatment plan daily based on real-time imaging to match the exact size and position of your prostate. Researchers want to see if the daily-adjusted approach reduces side effects, especially urinary problems, while treating your cancer effectively.

Prostate radiation therapy can cause uncomfortable side effects like urinary problems and bowel issues. By adjusting the treatment plan each day based on real-time imaging, doctors may be able to reduce radiation dose to healthy tissues around the prostate, potentially reducing these side effects while still effectively treating the cancer.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with localized prostate cancer that has not spread beyond the prostate and nearby lymph nodes
you have completed staging tests to confirm your cancer has not spread to distant parts of your body
you are in good enough health to participate in the study, as assessed by your doctor
you can commit to receiving 5 radiation treatments over about 18 days and follow-up visits for at least 3 years

You likely don't qualify if…

you have received previous radiation therapy to the pelvis or other treatments to destroy the prostate, such as cryosurgery or high-intensity focused ultrasound
you have a history of inflammatory bowel disease (Crohn's disease or ulcerative colitis) or a rare condition called ataxia telangiectasia
you have rare types of prostate cancer, such as neuroendocrine or small cell carcinoma
you have metastatic cancer (cancer that has spread to distant bones, organs, or lymph nodes above the kidneys)

What participation looks like

You will be randomly assigned to receive either standard radiation therapy or daily-adjusted radiation therapy. Either way, you will receive 5 radiation treatments over about 18 days, given either every other day or daily. Before treatment starts and throughout the study, you will have MRI or CT scans and blood tests. After your treatments end, you will have follow-up visits at 1, 3, 6, 9, 12, and 24 months to check for side effects and monitor how well the treatment worked.

Better radiation therapy planning for localized prostate cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)