Plain-English translation of NCT07278869 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This early feasibility study is testing the Append System, a new catheter-based procedure to treat atrial fibrillation (irregular heartbeat). Instead of leaving a permanent metal device in your heart, the Append System works by folding in a small pouch called the left atrial appendage and tying it off with a surgical stitch. Researchers will follow you for up to 5 years to make sure the treatment is safe and works as intended.
Many people with atrial fibrillation are at risk of dangerous blood clots forming in the heart, which can cause stroke. Current treatments either require taking blood thinners long-term or implanting a permanent metal device. This trial exists to see if there's a way to solve this problem without leaving anything permanent inside your heart.
You likely qualify if…
You likely don't qualify if…
You will undergo the Append System procedure, which is done through a catheter inserted in your groin—no open-heart surgery needed. During the procedure, doctors will fold the small pouch in your heart inward and tie it off with a stitch. After the procedure, you'll need to take specific blood-thinning and antiplatelet medications as directed. You'll then return for follow-up visits and evaluations over the next 5 years to monitor your safety and how well the treatment is working.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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