Plain-English translation of NCT07279259 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Stroke research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
When someone has an acute ischemic stroke, doctors give intravenous thrombolysis—a clot-busting medication injected into the bloodstream to restore blood flow to the brain. This trial is testing whether managing blood pressure differently during and after this medication might reduce serious bleeding complications and improve patient outcomes. The study will compare two approaches to blood pressure control in patients with elevated blood pressure at the time of treatment.
High blood pressure is common in stroke patients and can increase the risk of dangerous bleeding in the brain after clot-busting therapy. Doctors are not certain what the best blood pressure management strategy is during this critical time, so this trial aims to find the safest and most effective approach.
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If you qualify, you will be randomly assigned to receive either the usual blood pressure management approach or an adjusted blood pressure management strategy while receiving your clot-busting medication. Doctors and nurses will monitor your blood pressure closely and watch for any complications. You will have follow-up assessments at 7 days (or at hospital discharge if you leave before day 7) and again at 90 days to check your neurological function and recovery.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
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