Recruiting

Testing a new cancer drug versus standard chemotherapy for endometrial cancer

Plain-English translation of NCT07286331 on ClinicalTrials.gov ↗ · Source last updated October 2026 · Translation generated August 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing whether a new medication called works better than standard chemotherapy for endometrial cancer that hasn't responded to previous treatments. Researchers want to see if this medication helps people live longer and feel better, and whether it causes fewer or milder side effects than the chemotherapy options that are currently used. About 600 people will participate.

Endometrial cancer can return or progress even after patients receive platinum-based chemotherapy and immunotherapy. Doctors need better treatment options for these patients, and this trial is testing whether this medication could offer improved outcomes with better tolerability.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with endometrial cancer confirmed by a tissue biopsy
you have received one to two prior lines of cancer treatment (or up to three if one was given before surgery)
your cancer progressed despite platinum-based chemotherapy and immunotherapy treatment
you have at least one measurable tumor that can be tracked on imaging scans
you have provided a tumor tissue sample for testing that shows specific protein markers

You likely don't qualify if…

you have severe organ damage or serious medical conditions that would make chemotherapy unsafe
you are pregnant or breastfeeding
you have an active infection or uncontrolled autoimmune condition
you cannot commit to the study visits and follow-up appointments

What participation looks like

If you join this study, you will be randomly assigned to receive either the new medication or one of the standard chemotherapy drugs. You'll visit the study center regularly for treatment, blood tests, and imaging scans to see how well the medication is working. The study team will monitor you closely for side effects and track your health throughout the trial.

AI-generated summary from trial data · Aug 6, 2026 · Not medical advice

Trial locations(48 sites)

United States

GSK Investigational Site, Birmingham, Alabama

GSK Investigational Site, Omaha, Nebraska

Argentina

GSK Investigational Site, Florida, Buenos Aires

GSK Investigational Site, Mendoza, MD

GSK Investigational Site, Buenos Aires