Plain-English translation of NCT07293871 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Rheumatoid Arthritis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new treatment called SUSTAIN therapy, which uses ultrasound energy to help calm the immune system and reduce joint inflammation in people with rheumatoid arthritis. The study has two stages: first, a small group of patients will try the treatment to make sure it's safe and feasible, and then a larger group will be randomly assigned to receive either the real ultrasound treatment or a sham (fake) treatment that looks and feels the same but has no actual ultrasound energy.
Current treatments for rheumatoid arthritis don't work well enough for everyone, and some patients struggle with side effects. This medication uses ultrasound to activate nerves that may naturally calm inflammation, offering a potentially new way to help manage the disease.
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If you join this study, you will come to the study site every day for 8 weeks to receive treatment. Each session involves ultrasound therapy applied to your abdomen over the spleen area — it will feel similar to an ultrasound scan you might have at a doctor's office. Half of participants will receive the active ultrasound treatment, and half will receive a sham treatment that looks identical but delivers no ultrasound energy. You'll also have regular check-ins where doctors will measure your joint tenderness, swelling, and blood inflammation markers to see if the treatment is helping.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
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