Testing a Neck Surgery to Help Alzheimer's Disease Memory Loss

This trial is testing a microsurgical technique called deep cervical lymphatic-venous anastomosis, which connects tiny lymphatic vessels in the neck to nearby veins to improve how fluid drains from the brain. Doctors in China have noticed that patients sometimes show early improvements in memory, mood, and thinking skills after this surgery, but these improvements don't always last. This study will compare the actual surgery to a sham surgery (where doctors make an incision but don't perform the full procedure) to understand whether the improvements come from the surgery itself or from other factors like anesthesia or the surgical experience.

Early reports suggest the surgery may help Alzheimer's symptoms, but researchers don't know if the improvements are real or if they're caused by something else about the surgical process. This trial will use a sham surgery comparison to find out whether the surgery truly helps or if other aspects of the procedure are responsible.