Recruiting

Understanding thinking problems in brain and mood disorders

Plain-English translation of NCT07295652 on ClinicalTrials.gov ↗ ·

What is this trial?

This research study is mapping how different brain and mood disorders affect thinking, memory, and decision-making. Researchers will ask you to complete cognitive tests—exercises that measure things like how you make decisions, remember information, and stay focused—and compare your results to healthy volunteers. Over time, they'll also look at brain scans and see how your thinking changes with treatment.

Doctors know that conditions like schizophrenia, depression, bipolar disorder, and neurological diseases can affect how people think and remember, but they don't fully understand which thinking problems are shared across disorders and which are unique to each one. This study will help create better testing tools and reveal patterns that could improve diagnosis and treatment.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with a psychiatric disorder like schizophrenia, depression, bipolar disorder, or obsessive-compulsive disorder, or a neurological disorder like epilepsy or a neurodegenerative disease
you are willing and able to give written informed consent
you are affiliated with a social security scheme (have valid insurance or health coverage)
you are a healthy volunteer with no history of psychiatric or neurological disorders (for the control group)

You likely don't qualify if…

you currently take psychiatric medications or have an active psychiatric diagnosis (if you are a healthy volunteer)
you have a history of depression
you have a neurological history such as stroke, coma, epilepsy, or neurodegenerative disease (if you are a healthy volunteer)
you have a substance use disorder (other than tobacco)
you have a pacemaker, heart valve implant, or metallic object in your body that would prevent you from safely having an MRI scan

What participation looks like

You will complete a series of cognitive tests that measure thinking, memory, and decision-making—some on paper, some on a tablet or computer. If you are undergoing treatment (like medication, therapy, or brain stimulation), you may be asked to return for repeat testing before and after your treatment to see how your thinking changes. Researchers may also invite you for a brain scan (MRI, EEG, or MEG) to see the brain activity behind any thinking differences they find.

Understanding thinking problems in brain and mood disorders

What is this trial?

Do you qualify?

What participation looks like

Trial locations(3 sites)