Recruiting

Testing a new medication for hard-to-control type 2 diabetes

Plain-English translation of NCT07296484 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Read our Type 2 Diabetes research guide →

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new medication called for people with type 2 diabetes that is hard to control, especially those who also have elevated cortisol levels (a hormone that affects blood sugar). The study will test different doses of the medication or a placebo over 24 weeks to see which dose works best at improving blood sugar control. The goal is to find out if this treatment can help people whose diabetes hasn't responded well to their current medicines.

Many people with type 2 diabetes struggle to control their blood sugar even while taking multiple diabetes medications. This trial exists because researchers believe that high cortisol levels may be contributing to this problem, and this medication may help by reducing cortisol's effects on blood sugar.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with type 2 diabetes that is difficult to control (HbA1c level of 7.5% or higher) despite being on stable diabetes medications
you have been taking at least 2 diabetes medications at adequate doses for at least 3 months
you have elevated cortisol levels confirmed by a specific hormone test, or you have a known non-cancerous condition causing cortisol excess
you have at least one sign of severe or complicated diabetes, such as eye damage, kidney problems, nerve damage, heart disease, high blood pressure requiring multiple medications, or a history of osteoporosis or fractures

You likely don't qualify if…

you were diagnosed with diabetes less than 1 year ago
you are unwilling to keep taking your current diabetes medications during the trial or to adjust them as the study doctor directs
you are unwilling to use continuous glucose monitoring devices or follow other trial procedures
you frequently work night shifts or are regularly awake between 11 p.m. and 7 a.m.
you have experienced severe low blood sugar episodes that required help from someone else, or you have had multiple documented episodes of low blood sugar in the past 3 months

What participation looks like

The trial has two main phases. First, you'll go through a screening period of 5 to 9 weeks, which includes initial eligibility checks and a special hormone test (dexamethasone suppression test) to confirm elevated cortisol levels. If you qualify, you'll then be randomly assigned to take either a placebo or one of four different doses of the medication as a daily tablet for 24 weeks. You'll have regular visits to check your blood sugar, and the study team will monitor how well the treatment is working. After your 24 weeks of treatment, you'll have a follow-up phone call 4 weeks later.

AI-generated summary from trial data · Jun 25, 2026 · Not medical advice

Trial locations(60 sites)

United States

Arizona Clinical Trials - Pecos, Chandler, Arizona

Arizona Clinical Trials - Broadway, Tucson, Arizona

Ark Clinical Research - Fountain Valley, Fountain Valley, California

Velocity Clinical Research, Huntington Park, Huntington Park, California

Velocity Clinical Research - Gardena, La Mesa, California