Recruiting

Water Uptake Patterns to Predict Stroke Treatment Success

Plain-English translation of NCT07299981 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

This is a research study looking at people who received intravenous thrombolysis—an emergency treatment that dissolves blood clots during a stroke. Researchers want to see if a specific measurement on brain scans taken at admission can predict which patients will have better or worse outcomes after treatment. The study compares this scan measurement to patients' actual recovery over time.

Current stroke treatment decisions are based mainly on how much time has passed since the stroke started, but patients' brains respond differently depending on how quickly the damage is spreading. This study aims to find a better way to measure the true 'ticking clock' of brain injury, which could help doctors make smarter decisions about who will benefit most from this treatment.

Do you qualify?

You likely qualify if…

you were treated with intravenous clot-dissolving medication for an acute stroke
you had a non-contrast brain CT scan when you arrived at the hospital
you had a follow-up brain scan (CT or MRI) between 12 and 24 hours after treatment
your final infarct volume (the area of brain damage) was larger than 5 milliliters
your admission scan included an ASPECTS score (a standard stroke severity measurement)

You likely don't qualify if…

you were taking blood thinners by mouth when you arrived at the hospital
you had signs of an earlier stroke already visible on your admission brain scan
you had a large vessel blockage and also received mechanical thrombectomy (a catheter procedure to remove the clot)
your brain scans were of poor quality and couldn't be accurately measured
you have severe white matter disease that makes brain scans hard to interpret

What participation looks like

As a participant, you would not need to do anything active—this is a research study that uses medical records and scans you've already had. Researchers will collect your admission and follow-up brain scans and analyze the water uptake patterns in your brain tissue to see if these patterns connect to your recovery. The study involves no additional visits, treatments, or procedures beyond the standard care you already received.

AI-generated summary from trial data · Jul 19, 2026 · Not medical advice

Trial locations(1 site)

Austria

Department of Neurology, St. John's Hospital, Vienna, Austria, Vienna, 1020, Vienna