Plain-English translation of NCT07300553 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Researchers believe that changes in gut bacteria may disrupt how immune cells use energy, which could contribute to inflammatory bowel disease (IBD). This study will examine the connection between gut bacteria and immune cell metabolism in healthy volunteers and people with Crohn's disease or ulcerative colitis. By tracking how your body processes a special type of fiber and analyzing your blood, urine, and stool, researchers hope to understand whether restoring healthy gut bacteria could help control IBD.
Many people with inflammatory bowel disease struggle with poor disease control and reduced quality of life, even with current treatments. Understanding how gut bacteria affect immune cell energy metabolism may reveal new ways to treat IBD and improve outcomes.
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If you are a healthy volunteer, you will visit the research clinic twice: once before antibiotic treatment and once after a week of antibiotics. At each visit, you will fast overnight, provide a blood sample, eat a special breakfast with labeled fiber, then provide blood samples hourly for up to 10 hours, plus all urine and stool samples collected that day. If you have IBD, you will have one visit following the same process. The study will track how your body and gut bacteria process the labeled fiber through blood, urine, and stool analysis.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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