How well does a new treatment work for severe bowel inflammation in everyday practice

This is a real-world study following patients in China who have moderate-to-severe ulcerative colitis (a long-term inflammatory bowel disease) and are starting treatment with guselkumab. Researchers will track how well this medication works and how it affects patients' symptoms and quality of life by collecting information from their regular doctor visits and medical records. The study is not providing the medication—patients receive it as part of their normal medical care.

Ulcerative colitis can be very difficult to treat, and doctors want to understand how well this medication performs when used in regular clinical practice, not just in controlled research settings. This information will help doctors in China better understand whether this treatment is effective for patients who have never tried other advanced biologic therapies before.