Plain-English translation of NCT07303582 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This pilot trial is testing a newer treatment called cryoneurolysis—a technique that uses controlled freezing to calm overactive nerves—against the standard treatment, botulinum toxin injections, for managing pain caused by spasticity (involuntary muscle tightness). Both treatments would be combined with your usual care. The researchers want to see if cryoneurolysis can provide relief that lasts longer and requires fewer repeat treatments than botulinum toxin.
Many people with neurological conditions like stroke, spinal cord injury, and multiple sclerosis experience painful muscle stiffness that limits their mobility and quality of life. Current treatments like botulinum toxin injections work for some people but require repeated treatments every few months, and oral medications can cause side effects like drowsiness. This trial explores whether the new treatment might offer longer-lasting relief with fewer burdens on patients.
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You would be randomly assigned to receive either cryoneurolysis (nerve freezing) or botulinum toxin injections, along with your regular care. The trial would involve visits to Oxford University Hospitals NHS Trust where your pain and muscle stiffness would be assessed, and you would receive your assigned treatment. You would then be followed over time to track how well the treatment works for your pain and how long the benefits last.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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