New treatment combining electric pulses and immune therapy for advanced pancreatic cancer

This trial is testing a new combination approach for people with locally advanced pancreatic cancer whose standard first chemotherapy (called AG therapy) didn't work. The treatment combines two things: irreversible electroporation (IRE)—a procedure that uses electrical pulses to destroy cancer cells—and a medication called Apalulizumab, which helps your immune system fight the cancer. The goal is to see if combining these two approaches can help more patients and give doctors a better second-line treatment option.

Pancreatic cancer is very aggressive, and when standard chemotherapy stops working, patients have limited options. Researchers believe that combining the electric pulse procedure with immune therapy might be more effective than either treatment alone, offering hope to people who have run out of conventional choices.