Plain-English translation of NCT07308873 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is trying to understand why people with knee arthritis have such different experiences with pain — even when their X-rays look similar. Researchers will ask you questions about your pain and mood, have you walk while they measure your movement, and take images of your knee and brain. By studying these factors together, they hope to find new ways to help people with knee arthritis stay active and feel better.
Right now, doctors can't predict which patients with knee arthritis will have disabling pain and which won't, even when the joint damage looks the same on X-rays. This study aims to uncover the hidden reasons behind these differences — including how your brain processes pain — so doctors can develop better treatments tailored to each person's needs.
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You will come to the University of Pittsburgh for two study visits where you'll complete surveys about your pain and mood, have your knee and brain imaged with an MRI scanner, and perform walking and movement tasks while researchers measure how you move. The visits will include assessments of your strength and balance, and you'll be asked detailed questions about how pain affects your daily activities. The entire study takes place over a few weeks, and the researchers will use all this information to identify patterns in how your body and mind respond to movement.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
United States
Sponsor
University of Pittsburgh
Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Enrollment target
~300 participants
Started
January 2026
Primary completion
August 2030
Age range
45 Years – 80 Years
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Benedict Alter, MD, PhD
University of Pittsburgh
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.