Plain-English translation of NCT07309523 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →Researchers at the University of Leeds want to understand why hearts fail in some people, especially those with diabetes. This study will examine how the heart uses energy and how that relates to problems with heart rhythm and pumping strength. By studying muscle tissue, blood, and heart function in people with different combinations of heart failure and diabetes, scientists hope to identify the metabolic (energy-use) problems that drive heart disease.
When the heart fails, it often loses its ability to pump harder when the body needs it to — a problem called an abnormal force-frequency relationship. Researchers believe this happens because of metabolic problems (the way cells use energy), and that diabetes may make this worse. This study aims to find out exactly which energy pathways go wrong, so doctors can eventually develop better treatments.
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As a participant, you will undergo specialized heart and muscle tests, likely including cardiac imaging, blood tests, and possibly muscle biopsies to measure how your heart and muscles use energy at rest and during increased heart rate. The study is observational, meaning researchers will monitor and measure your heart function rather than give you a new medication to test. Your participation will be tied to your pacemaker implant procedure, which is already clinically indicated for your care.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United Kingdom