New MRI scan method to predict stroke risk in brain artery narrowing

Plain-English translation of NCT07309718 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated July 2026 · How we translate trials

What is this trial?

Researchers are studying a new way to use MRI scans to predict stroke risk in people who have narrowed arteries inside the brain. This condition, called intracranial atherosclerotic stenosis, can lead to stroke, but doctors don't always know which patients are at highest risk. This trial will test whether a specialized MRI measurement—called the MRI-derived pressure ratio—can help doctors identify who needs more aggressive treatment.

Many patients with narrowed brain arteries don't have another stroke, but some do—and doctors currently have limited tools to tell the difference. This trial exists to see whether the new MRI measurement can safely and accurately predict which patients are most at risk, so doctors can tailor treatment more precisely.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with moderate to severe narrowing (50–99%) of an artery inside your brain in the front part of your head
your narrowing was confirmed by standard imaging tests such as ultrasound, CT angiography, MR angiography, or angiography
you are able and willing to sign a consent form before the study begins
you can undergo MRI scans without metal implants or severe claustrophobia

You likely don't qualify if…

you have a rare brain artery condition unrelated to atherosclerosis, such as moyamoya disease or vasculitis
you have significant narrowing (over 50%) in the neck artery on the same side as your brain artery narrowing
you have had a very large recent stroke affecting more than half of a major brain region
you cannot take blood thinners or cholesterol-lowering medications due to allergies or medical contraindications
you have metal implants or severe claustrophobia that prevents MRI scanning

What participation looks like

If you join, you will visit the study center for an initial evaluation and then return for follow-up visits at 1 month, 6 months, and 12 months after enrollment. During these visits, you will receive standard stroke prevention medications (blood thinners and cholesterol medications) and undergo specialized imaging tests, including MRI scans and possibly ultrasound or CT scans, to measure blood flow and artery narrowing. The study will track whether you have a stroke or other health events over the year of follow-up.

AI-generated summary from trial data · Jul 4, 2026 · Not medical advice

Trial locations(1 site)

China

Department of Neurosurgery, Xuanwu hospital, Beijing, Xicheng District

New MRI scan method to predict stroke risk in brain artery narrowing

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)

Key details

Contact the research team directly

Interested in joining?