Plain-English translation of NCT07312760 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing ORPHYS, a short-term talk therapy designed specifically for people with serious illnesses like advanced cancer. The therapy helps patients work through deep existential fears, hopelessness, and the emotional weight of living with uncertainty. Researchers want to see if this specialized therapy helps people feel more hopeful and improve their quality of life compared to standard psychological support.
As cancer treatments have improved and people live longer with advanced cancer, many patients struggle with overwhelming fear about the future, loss of hope, and a sense of despair. Standard care doesn't always address these deep emotional and spiritual struggles. This trial aims to find out whether this focused therapy can better help patients navigate these feelings and find meaning and adaptation.
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If you join this trial, you would be randomly assigned to either receive the specialized talk therapy (15–31 sessions) or continue with standard psychological care. You would attend assessment appointments at the start and then at 3, 6, 9, and 12 months to measure how you're doing emotionally. The therapy sessions help you work through your fears and find ways to cope, while the assessments track changes in your mood, hope, anxiety, and overall quality of life.
AI-generated summary from trial data · Jul 9, 2026 · Not medical advice
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