Recruiting

Brain injection treatment to improve movement after stroke

Plain-English translation of NCT07318714 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This is an early-stage study testing a new medication called for people who have difficulty moving after a stroke. The medication is injected directly into the damaged area of the brain during surgery. The study aims to find the safest dose and learn whether this treatment can help people regain better movement and function.

Many people who have strokes are left with lasting movement problems that don't fully recover on their own. This medication is being tested to see if delivering it directly to the injured brain tissue could help restore lost movement abilities in a way current treatments cannot.

Do you qualify?

You likely qualify if…

you had your first and only stroke between 3 and 12 months before joining the study
you have moderate difficulty with arm and leg movement as a result of your stroke
your stroke was caused by a small blood clot in a specific area of the brain (supratentorial perforator region)
you have completed initial rehabilitation and doctors don't expect further natural improvement on your own
you are willing and able to participate in physical therapy during the study

You likely don't qualify if…

you have had a previous stroke before the one being studied
you have severe movement loss or very minimal movement loss from your stroke
you have had any bleeding in the brain or a history of brain hemorrhage
you are pregnant, breastfeeding, or unwilling to use contraception for 6 months after surgery
the damaged area from your stroke is very large or very small on brain imaging

What participation looks like

If you qualify, you will undergo stereotactic brain surgery—a precise, minimally invasive procedure—where doctors inject the medication (or a sham procedure with no injection) directly into the stroke-damaged area. You will stay in the hospital for about 2 weeks after surgery, then receive physical therapy and have safety check-ups for about 1 year. Neither you nor most of the study doctors will know whether you received the actual medication or the sham procedure, which helps ensure fair results.

Brain injection treatment to improve movement after stroke

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)