Plain-English translation of NCT07321197 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether removing lymph nodes during kidney cancer surgery improves survival outcomes for patients with high-risk disease. Researchers will compare two surgical approaches: removing just the affected kidney versus removing the kidney along with a carefully mapped set of nearby lymph nodes. The goal is to determine if the extra surgery to remove lymph nodes helps prevent cancer from coming back or spreading.
Past studies in patients with early-stage kidney cancer found that removing lymph nodes didn't help, so the practice was largely stopped. However, newer evidence suggests that patients with more advanced or aggressive kidney cancers may actually benefit from lymph node removal because it can find and eliminate hidden cancer spread. This trial will test whether this new treatment approach truly helps patients with high-risk disease.
You likely qualify if…
You likely don't qualify if…
If you enroll, you will be randomly assigned to one of two surgical groups: one group will have kidney removal surgery alone, and the other group will have kidney removal plus removal of nearby lymph nodes according to a specific template map. The surgery may be performed using open, laparoscopic, or robot-assisted techniques depending on your surgeon's expertise. After surgery, you will be followed over time with regular visits and imaging to monitor how well you are doing and whether your cancer returns.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
China