New immunotherapy combined with chemotherapy before surgery for advanced ovarian cancer

Plain-English translation of NCT07322094 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new immunotherapy medication called TORL-1-23 combined with chemotherapy to treat advanced ovarian cancer and related cancers. The study will give you the medication along with chemotherapy drugs before your surgery, and then monitor how well this combination works and how safe it is.

Advanced ovarian cancer is difficult to treat, and doctors are looking for better ways to help patients before surgery. This medication is being tested to see if it can boost the body's immune system to fight the cancer more effectively when used with standard chemotherapy.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced stage ovarian, fallopian tube, or primary peritoneal cancer (stage III or IV)
your cancer cells test positive for a protein called claudin 6
you have not received any chemotherapy or other cancer treatment before
you have not had surgery for this cancer
your overall health is strong enough to handle the treatment (assessed by your doctor)

You likely don't qualify if…

you have received chemotherapy, immunotherapy, or radiation to your abdomen or pelvis before
you have already had surgery for this cancer
you have cancer that has spread to your brain and is causing symptoms
you are pregnant or breastfeeding
you have other serious medical conditions that are not well controlled

What participation looks like

You would receive the medication and chemotherapy infusions once every three weeks before your planned cancer surgery. The trial involves different treatment combinations, so you may receive one or two chemotherapy drugs along with the new medication. Throughout the study, you'll have regular doctor visits, blood tests, and scans to monitor your response to treatment and check for any side effects.

AI-generated summary from trial data · Jun 12, 2026 · Not medical advice

Trial locations(7 sites)

United States

Providence St. Jude Medical Center, Fullerton, California

City of Hope, Irvine, California

University of Southern California, Los Angeles, California

UCLA, Los Angeles, California

The Mayo Clinic, Rochester, Minnesota