Plain-English translation of NCT07323745 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a medication called Mobithron Advance to see if taking it daily for one year can help slow the breakdown of cartilage in the knee and ease pain in people over 50 with osteoarthritis. Researchers will use MRI scans, pain surveys, and physical function tests to track whether the medication protects your knee cartilage over time. They will also monitor your kidney function to make sure the treatment is safe.
Knee osteoarthritis causes the protective cartilage in your joint to wear down over time, leading to pain and difficulty moving. This medication has shown promise in early testing, and doctors want to know if this treatment can slow that damage and help people stay more active and comfortable.
You likely qualify if…
You likely don't qualify if…
You would take one tablet of the medication by mouth every day for 12 months at an orthopaedic clinic in Malaysia. During that year, you'll have regular follow-up visits where doctors will check your pain using a simple scale, test your physical function, take MRI scans of your knee (at the start, 6 months, and 12 months), and monitor your kidney health with blood tests. The study involves monthly check-ins to track how you're doing and whether you're experiencing any side effects.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
Malaysia