Recruiting

Two ways to decide which heart blockages need treatment

Plain-English translation of NCT07324720 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated July 2026 · How we translate trials

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This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study compares two different strategies for treating blocked heart arteries in high-risk patients. One strategy uses detailed imaging cameras to look at the plaque buildup and identify weak spots in the artery walls, while the other uses pressure measurements to see if the blockage is actually causing the heart muscle to struggle for oxygen. The goal is to see which approach leads to better outcomes for patients.

Doctors currently have two ways to decide whether a blocked artery needs treatment, but it's not clear which method works better for high-risk patients. This trial will help answer that question so doctors can make the best decisions for future patients with serious heart disease.

Do you qualify?

You likely qualify if…

you are 19 years old or older
you have moderate to severe blockages in your heart arteries (50–90% narrowing) that are newly discovered
you have at least one major risk factor, such as diabetes, kidney disease, a recent heart attack, or a history of heart attack
you have complex or risky artery blockages, such as blockages at artery branches, heavily calcified blockages, or blockages in multiple locations
you understand the risks and benefits of the study and agree to follow-up visits

You likely don't qualify if…

you are allergic or unable to take blood thinners, aspirin, or heart medications used in the procedure
you have severe blockage in your left main coronary artery (the largest artery supplying your heart)
you have had previous heart bypass surgery
you have severe asthma or severe lung disease that would make the test medication unsafe
you have a bleeding disorder or have had major bleeding in the past 3 months, or your life expectancy is less than 2 years due to other serious conditions

What participation looks like

If you join this trial, you will receive a heart catheterization procedure where a thin tube is threaded to your heart arteries. Depending on which group you're assigned to, your doctor will either use specialized imaging cameras to examine your artery blockages in detail, or use pressure measurements to assess how much the blockages are limiting blood flow. Based on these findings, your doctor will decide whether to place stents (small mesh tubes) to open blocked arteries. You will then return for follow-up visits to monitor your health and recovery.

AI-generated summary from trial data · Jul 1, 2026 · Not medical advice

Trial locations(1 site)

South Korea

Seoul National University Hospital, Seoul, Main Building

View full record on ClinicalTrials.gov