Recruiting

Two medications before liver cancer surgery to reduce recurrence

Plain-English translation of NCT07324824 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing whether —two medications that help your immune system fight cancer and block blood vessel growth to tumors—can be given before liver cancer surgery to help prevent the cancer from returning. The study involves 37 people with advanced hepatocellular carcinoma (liver cancer) that doctors believe can still be surgically removed. Previous research suggests this medication combination works better than older treatments for advanced liver cancer.

Right now, even after surgery to remove liver cancer, the cancer comes back in up to 70% of patients. Doctors want to know if giving the new treatment before surgery—rather than waiting until after—can lower that recurrence rate and help people live longer. There is currently no standard treatment given before liver cancer surgery, so this trial is exploring whether this medication combination could become that standard approach.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with or had a biopsy confirming advanced liver cancer that can still be surgically removed
you have not received any prior treatment for liver cancer
you are in good overall health with a performance status score of 0–1 (able to carry out most normal activities)
you have good liver function, specifically Child-Pugh class A (a measure of how well your liver is working)

You likely don't qualify if…

you have a history of bleeding problems, blood clots, stroke, heart attack, or serious bleeding events in the past 6 months
you have uncontrolled high blood pressure, heart failure, or serious heart rhythm problems
you have had major surgery or unhealed wounds within the past 4 weeks
you have a history of organ transplant, liver encephalopathy, or signs of severe portal hypertension with bleeding risk
you have a history of lung disease like pulmonary fibrosis or interstitial pneumonia

What participation looks like

If you qualify, you will receive (the medication) through intravenous infusions given before your scheduled liver cancer surgery. The study will monitor how well the medication shrinks your tumor, whether surgery can successfully remove it, and how the treatment affects your cancer recurrence and overall survival after surgery. You will have regular clinic visits, blood tests, and imaging scans to track your progress throughout the trial.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Two medications before liver cancer surgery to reduce recurrence

What is this trial?

Do you qualify?

What participation looks like

Trial locations