Testing a new inhaled treatment to reduce mouth sores from cancer therapy

Plain-English translation of NCT07327216 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

Nasopharyngeal cancer is often treated with combined chemotherapy and radiation therapy, which can cause severe, painful mouth sores that sometimes force patients to stop treatment early. This trial is testing whether , an inhaled medication, can reduce the likelihood and severity of these mouth sores compared to a standard steroid treatment. The study will help doctors find a better way to protect patients' mouths during this intensive cancer treatment.

Mouth sores from combined chemotherapy and radiation are so painful and debilitating that many patients cannot complete their full course of cancer treatment, which can reduce the effectiveness of the therapy. Currently, there is no proven medication that works reliably for everyone, so researchers are testing this medication to see if it offers better protection.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced nasopharyngeal cancer (stage III or IVa) confirmed by a pathology test
you have never received radiation therapy, chemotherapy, surgery, or immunotherapy before
you are between 18 and 75 years old
you are in good overall health (Karnofsky Performance Status score of 80 or higher)
your blood counts and liver and kidney function are normal or near-normal before starting treatment
you have normal, healthy mouth tissue with no existing mouth sores before treatment begins

You likely don't qualify if…

you have a history of other cancers or current cancer outside the nasopharynx
you have asthma, severe allergies, or a history of allergic skin reactions
you have an autoimmune disease, connective tissue disease, or diabetes that affects wound healing
you are pregnant, breastfeeding, or planning to become pregnant during the study
you have serious heart, kidney, or acute infection problems that your doctor believes would be unsafe

What participation looks like

If you enroll, you will receive standard combined chemotherapy and radiation therapy for your cancer, plus a daily inhaled treatment from the first day of radiation through the end of your radiation course. You will be randomly assigned to receive either the new medication or a standard steroid medication () by inhalation once per day. Throughout your treatment, your doctors will monitor you closely for mouth sores, side effects, and how well the treatment is working, with regular check-ups and evaluations.

AI-generated summary from trial data · Jun 30, 2026 · Not medical advice

Testing a new inhaled treatment to reduce mouth sores from cancer therapy

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)