Plain-English translation of NCT07338773 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether giving vancomycin directly into the bone during foot amputation surgery works better than the traditional method of giving it through an IV before surgery. Doctors believe that for people with diabetes who have poor blood flow to their feet, delivering the medication directly at the surgical site might get higher doses of the antibiotic where it's needed most, which could help prevent dangerous infections after surgery.
People with diabetes who need foot amputations often have damaged blood vessels that prevent antibiotics from reaching the surgical area effectively. This trial wants to find out if this medication can work better by going directly to the surgical site instead of relying on the bloodstream to deliver it.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will be randomly assigned to receive the antibiotic medicine either through a bone injection during your amputation surgery or through an IV before surgery. The doctors will collect small samples of tissue and blood during and after your operation to measure how well the medication reaches the surgical area. You will be followed up afterward to check for any infections or complications related to your surgery.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
Turkey (Türkiye)