Plain-English translation of NCT07339332 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This early-stage trial is testing CT1195E CAR-T cells, a new type of treatment made from your own immune cells that have been specially engineered in a laboratory. Researchers believe this medication may help people whose lupus has not responded well to standard treatments like steroids and immunosuppressants. The study will gradually test different doses of the treatment to find the safest and most effective amount.
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes the immune system to attack the body's own tissues. Many people with severe lupus do not respond adequately to current medications, leaving them with ongoing pain, organ damage, and serious health complications. This trial is exploring whether this new cell-based treatment could help patients whose disease remains active despite standard therapy.
You likely qualify if…
You likely don't qualify if…
You will visit the research hospital for screening tests to confirm you qualify. If accepted, you will receive a single infusion of the engineered immune cells through an IV. The study will monitor you closely for 28 days after the infusion to watch for any side effects and to see how well the treatment works. Researchers will track your lupus activity, blood work, and overall health throughout this monitoring period and may continue follow-up visits afterward.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
China
Phase
Safety & dosing
Sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborators
CARsgen Therapeutics Co., Ltd.
Enrollment target
~12 participants
Started
January 2026
Primary completion
June 2027
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Qiubai Li
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.