Smart Radiation Planning to Protect Healthy Lung During Cancer Treatment

Plain-English translation of NCT07339644 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a new way to plan radiation therapy for lung cancer that uses special 4D CT imaging to identify which parts of your lungs are working well and need to be protected. Doctors will use this information to create a radiation treatment plan that avoids damaging your healthy, functioning lung tissue as much as possible while still treating your cancer effectively.

Radiation therapy for lung cancer can sometimes damage healthy lung tissue and cause long-term breathing problems. This trial aims to see if targeting radiation away from the healthiest parts of your lungs can reduce these side effects and preserve your lung function.

Do you qualify?

You likely qualify if…

you are between 18 and 85 years old
you have been diagnosed with lung cancer (including cancer that has spread to the lungs) and need radiation therapy
you are physically able to tolerate radiation therapy and have an adequate performance status (able to do light activities)
you can complete the special 4D CT imaging scan needed for treatment planning
you are able to attend follow-up appointments and complete breathing tests for up to 12 months

You likely don't qualify if…

you are pregnant or breastfeeding
you have severe heart or lung disease that would make radiation too risky
you have already received high-dose radiation to the same area of your chest
you have severe psychiatric or cognitive conditions that would prevent you from cooperating with treatment and follow-up
you cannot produce good quality 4D CT images needed to identify your healthy lung tissue

What participation looks like

You will receive standard radiation therapy for your lung cancer, but your treatment plan will be created using special 4D CT imaging that maps out your healthiest lung tissue to help doctors protect it. You'll have imaging scans, lung function breathing tests, and quality-of-life assessments at several time points: during treatment, at the end of treatment, and then at 1, 3, 6, and 12 months after you finish. The entire study involvement lasts about one year.

Smart Radiation Planning to Protect Healthy Lung During Cancer Treatment

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)