How a liver medication works in people with liver damage

This is an early-stage study testing how capivasertib — an experimental medication — works in people with moderate liver damage. Researchers will give participants a single dose of the medication and carefully measure how their bodies process it over several days. They'll compare results between people with liver damage and people with healthy livers to understand whether the liver damage affects how the medication works.

Before testing this medication in larger patient groups or for treating disease, researchers need to understand how it behaves in people whose livers don't work normally. People with liver damage may process medications differently, which could affect safety and how much of the medication actually helps.