Recruiting

Emergency Procedure to Restore Blood Flow in Acute Stroke

Plain-English translation of NCT07347665 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

When someone has an acute ischemic stroke caused by a blood clot blocking a specific part of the middle cerebral artery in the brain, doctors currently try to dissolve the clot with medication. This trial tests whether adding an emergency endovascular procedure—a minimally invasive surgery where doctors thread a catheter through blood vessels to physically remove the clot—works better than medication alone. The procedure aims to restore blood flow to the brain faster and reduce long-term disability.

Standard clot-busting medication doesn't always work quickly enough or completely enough for all patients. This trial is exploring whether the emergency procedure can help more patients recover better by restoring blood flow faster and more completely.

Do you qualify?

You likely qualify if…

you are between 18 and 84 years old
you have had an acute stroke caused by a blood clot in a specific part of the middle cerebral artery (confirmed by imaging)
you had a moderate to severe stroke (a score of 8 or higher on the National Institutes of Health Stroke Scale)
you were in good health before the stroke (able to carry out all usual activities)
you are either unable to receive standard clot-busting medication or it did not work for you
you can be enrolled and start the procedure within 24 hours of when your stroke symptoms began

You likely don't qualify if…

you have bleeding in the brain or signs of bleeding on your imaging
you are pregnant or might be pregnant
you have a severe allergy to contrast dye (beyond a mild rash)
you have a blood clotting disorder or are at very high risk of bleeding
you have tortuous or unusually shaped blood vessels that would make the procedure difficult or unsafe

What participation looks like

If you join this trial, you will be randomly assigned to receive either the emergency procedure plus standard medical care, or standard medical care alone. The procedure group will have the catheter-based clot removal performed within 30 minutes of being enrolled. You will be monitored closely during and after treatment, with imaging and neurological exams to assess how well the treatment worked and to watch for any complications. Your recovery and disability level will be tracked over time to compare outcomes between the two groups.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Trial locations(3 sites)

Japan

Hyogo Medical University, Nishinomiya, Hyōgo

Thailand

Thammasat University Hospital, Khlong Luang, Changwat Pathum Thani

Vietnam

S.I.S Can Tho International General Hospital, Can Tho, Can Tho City