Recruiting

Two types of prostate cancer surgery: which preserves function better?

Plain-English translation of NCT07348367 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial compares two ways to surgically remove the prostate in men with early-stage prostate cancer. One approach is the standard surgery used today, while the other is a newer technique called precision prostatectomy that aims to preserve the structures around the prostate that control sexual function and bladder control. Researchers want to see if the newer approach can help men maintain better quality of life after surgery without compromising cancer control.

Standard prostate cancer surgery effectively removes cancer but often causes serious side effects—about half of men lose sexual function, and many experience urinary leakage. This newer surgical technique was designed to address these problems by removing the cancer while being gentler to the surrounding nerves and tissues, but it has never been tested in a rigorous clinical trial.

Do you qualify?

You likely qualify if…

you have been diagnosed with early-stage prostate cancer (low- or intermediate-risk) and have chosen surgery as treatment
you are receiving your care at Henry Ford Health System
your prostate-specific antigen (PSA) blood test result is 20 or lower
your cancer is located primarily on one side of the prostate and has a Gleason score of 4+3 or lower
you had normal sexual function before surgery (or normal sexual function with the help of medication)

You likely don't qualify if…

you have received hormone therapy (androgen deprivation therapy) in the past 6 months
your cancer has spread to lymph nodes or other parts of your body
you have had previous prostate cancer treatment such as radiation
you have serious health conditions that make surgery unsafe or a life expectancy of less than 5 years
you have been diagnosed with any other type of cancer before

What participation looks like

If you join this study, you will be randomly assigned to receive either standard prostate cancer surgery or the newer precision surgery approach. You will have your chosen surgery performed at Henry Ford Health System. After surgery, you will be assessed at 12 months to measure how well you've recovered—specifically, whether you've maintained sexual function and bladder control, and whether the cancer has been effectively controlled. The study focuses on outcomes at this one-year mark.

AI-generated summary from trial data · Jul 21, 2026 · Not medical advice

Trial locations(1 site)

United States

Henry Ford Health, Detroit, Michigan

View full record on ClinicalTrials.gov