Plain-English translation of NCT07349303 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a single dose of , a medication that helps your immune system recognize and fight cancer cells, can work better if given before surgery for thick melanoma. Half of the participants will receive the real medication, and half will receive a placebo (a dummy treatment with no active drug). The goal is to see if this medication can shrink or destroy cancer cells before surgery happens.
Thick melanomas have a higher risk of coming back or spreading after surgery. Researchers want to know if preparing the immune system with this medication before surgery might help prevent the cancer from returning and improve outcomes for patients.
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You will first have a small biopsy to confirm your diagnosis. Then you'll receive either one dose of or a placebo as an intravenous infusion. Four weeks later, you'll have surgery (wide local excision) to remove the melanoma and a sentinel lymph node biopsy to check if cancer has spread. Researchers will then examine the tissue removed during surgery to see how much the cancer responded to the treatment (or placebo) you received before surgery.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
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