Recruiting

Testing a new ointment for moderate to severe eczema in adults

Plain-English translation of NCT07355075 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This is a Phase 2 clinical trial testing GX-03, a topical ointment containing an ingredient called polyhexanide (PHMB), for people with moderate to severe eczema. Researchers want to see if this medication is safe and effective at reducing eczema symptoms compared to a placebo ointment (which looks identical but has no active ingredient). You would use whichever ointment you're assigned to twice daily for 8 weeks.

Eczema can be uncomfortable, itchy, and significantly affect quality of life, and many people need better treatment options. This trial is designed to see whether this medication could be a helpful new choice for adults struggling with moderate to severe eczema.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with moderate to severe eczema
you are in good general health according to your medical history
you can commit to applying the study ointment twice daily for 8 weeks
you are willing to use only the assigned study product on the affected areas during the trial

You likely don't qualify if…

you are pregnant, breastfeeding, or planning to become pregnant during the study
you have used topical or oral steroids or other immune-suppressing medications in the past 3 weeks
you have used other topical medications at the test sites in the past 72 hours
you have sunburn, tattoos, scars, or uneven pigmentation at or near the areas to be treated
you have another skin condition that could interfere with the study results

What participation looks like

You would visit the research clinic at the start, at week 4, and at week 8. At each visit, the study team would assess your eczema using standardized tools and ask you about any side effects. Between visits, you would apply your assigned ointment (either the active medication or placebo) to affected areas at least twice daily and keep track of your symptoms. The entire study lasts 8 weeks, and researchers may also check in with you weekly to make sure everything is going safely.

Testing a new ointment for moderate to severe eczema in adults

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)