Brain implant to help locked-in patients communicate

Plain-English translation of NCT07357428 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

The Connect-One Study is testing a new brain implant called the Connexus Brain-Computer Interface (BCI). This device is designed to decode signals directly from your brain to help you communicate and control computers, even if you have severe paralysis or cannot speak. The study aims to gather early safety information about how well this technology works.

People with severe paralysis or conditions that affect speech often lose the ability to communicate with others. This trial exists to explore whether a brain implant could restore that vital human connection by translating your thoughts into words and allowing you to interact with devices again.

Do you qualify?

You likely qualify if…

you have been diagnosed with a progressive neuromuscular disease or brain/spinal cord injury
you cannot speak or have severe difficulty speaking
you use a wheelchair and have severely limited arm and hand function
you can read and understand English and have a reliable way to communicate right now
you have a caregiver or family member willing to support you throughout the study
you live within 4 hours of a study site

You likely don't qualify if…

you have significant memory loss or a psychiatric condition that would make it hard to follow study instructions
you have other serious medical conditions that would interfere with your ability to participate safely
you have another implanted device like a pacemaker or deep brain stimulator
you need regular MRI scans for your medical care
your doctor believes the study would put you at too much risk

What participation looks like

As one of only 2 participants in this early feasibility study, you would undergo surgery to have the Connexus brain implant placed. After recovery, you would work with the research team to test how well the device allows you to communicate and control computers using your thoughts. The study involves regular visits to the research site and close monitoring of the implant's safety and function.

AI-generated summary from trial data · Jun 1, 2026 · Not medical advice

Trial locations(3 sites)

United States

University of California, Davis, Sacramento, California

Massachusetts General Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan