Plain-English translation of NCT07358468 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is watching how the uterus naturally contracts during frozen embryo transfer to understand whether these muscle movements help or hurt your chances of a successful pregnancy. Researchers believe that excessive uterine contractions might push the embryo out or prevent it from implanting properly, while gentler, slower contractions might improve success rates. The study will use ultrasound imaging to measure these contractions and track whether they relate to live birth outcomes.
Most research on uterine contractions has focused on fresh embryo transfers or natural pregnancy, leaving a gap in understanding how this matters for frozen embryo transfer. By learning which contraction patterns support successful implantation, doctors may eventually be able to predict or improve your chances of pregnancy.
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If you enroll, you will undergo frozen embryo transfer using a modified natural cycle approach, which involves a hormone injection to trigger ovulation when your follicle reaches a certain size, followed by progesterone suppositories to support the pregnancy. Ultrasound imaging will measure your uterine contractions before and after the embryo transfer to record the wave-like muscle activity. You will continue progesterone support through your pregnancy test and, if positive, through 10 weeks of pregnancy. The study will track whether these contraction patterns relate to whether you achieve a live birth.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
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