Comparing two tiny implants for treating open-angle glaucoma

Plain-English translation of NCT07359547 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether two different minimally invasive implants work equally well at lowering eye pressure in people with open-angle glaucoma. You would be randomly assigned to receive one of two devices—the XEN-63 Gel Stent or the PRESERFLO MicroShunt—during a single eye surgery. Researchers want to see which implant is most effective at controlling eye pressure over two years.

Open-angle glaucoma can lead to vision loss if eye pressure isn't controlled with medications alone. This study will help doctors understand whether these two newer surgical implants are effective alternatives for patients whose glaucoma isn't well controlled with eye drops.

Do you qualify?

You likely qualify if…

you are over 40 years old
you have been diagnosed with open-angle glaucoma, normal tension glaucoma, pigment dispersion glaucoma, or pseudoexfoliative glaucoma
your eye pressure is not adequately controlled even with maximum tolerated eye drop therapy
your eye pressure is between 14–28 mmHg at the time of screening
your cornea has adequate cell health (endothelial cell count of at least 1000 cells per square millimeter)

You likely don't qualify if…

you have closed-angle glaucoma or secondary open-angle glaucoma (other than the specific types listed)
you have had previous glaucoma surgery, shunt placement, or laser treatment within the last few months
you are currently taking oral or eye drop corticosteroids
you have active eye inflammation, infection, or surface disease
you have had recent eye surgery involving the white part of the eye within the last three months

What participation looks like

You will have one surgical procedure to place either the XEN-63 Gel Stent or the PRESERFLO MicroShunt in your eye. After surgery, you'll attend regular follow-up visits over 24 months where doctors will measure your eye pressure, test your vision and visual field, take eye imaging scans, and check the health of your eye cells. You'll also report any side effects or additional treatments you receive during this time.

AI-generated summary from trial data · Jun 12, 2026 · Not medical advice

Comparing two tiny implants for treating open-angle glaucoma

What is this trial?

Do you qualify?

What participation looks like

Trial locations(3 sites)