Testing a new cell therapy for hard-to-treat autoimmune diseases

Plain-English translation of NCT07361094 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 ·

What is this trial?

This study is testing a new treatment called for people with autoimmune diseases that have not responded well to standard medications. The treatment uses your own immune cells, which are collected from your blood, modified in a laboratory to target the specific immune cells causing your disease, and then returned to your body. Researchers will carefully monitor your safety and how well the treatment works over two years.

Many people with autoimmune diseases like lupus, scleroderma, or multiple sclerosis do not improve adequately with current treatments, or their disease keeps flaring up despite being on medication for years. This trial exists to explore whether this new cell-based approach could offer hope for patients whose diseases are difficult to control.

Do you qualify?

You likely qualify if…

you are between 18 and 70 years old
you have been diagnosed with one of the autoimmune diseases in the study (such as lupus, systemic sclerosis, inflammatory muscle disease, Sjögren's syndrome, autoimmune hemolytic anemia, or multiple sclerosis)
your disease has not responded well to standard treatments or keeps coming back despite being on medication
you previously tried a single-target CAR-T therapy and it did not work, with at least 6 months having passed since that treatment
you have been on stable standard autoimmune therapy for at least 6 months before enrolling, but your disease is still active

You likely don't qualify if…

you have a serious infection or cancer
you are pregnant or breastfeeding
you have severe kidney, heart, or liver disease
you have received certain other recent treatments that might interfere with this therapy
you are unable to commit to the two-year follow-up monitoring schedule

What participation looks like

If you join this study, your blood will be collected so your immune cells can be taken out and modified in the laboratory over several weeks. You will also receive preparatory treatment to help your body accept the new cells. Then you will receive a single infusion of the modified cells back into your body. After that, you will have regular visits and tests over two years to check your safety and how well the treatment is working, including blood tests and disease activity assessments.

Testing a new cell therapy for hard-to-treat autoimmune diseases

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)