Plain-English translation of NCT07363278 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying the brain safety of a newer heart rhythm treatment called the VARIPULSE system, which uses electrical pulses to treat atrial fibrillation (an irregular heartbeat). Researchers want to understand whether this treatment causes silent brain lesions—tiny injuries you can't feel but that show up on brain scans. The study will compare brain imaging and memory tests before and after treatment to see if the VARIPULSE system is safer for the brain than older heat-based treatments.
Previous heart rhythm treatments using heat energy have been known to sometimes cause these tiny, silent brain injuries in up to 40% of patients. Because the VARIPULSE system uses electrical pulses instead of heat, it may be safer—but we don't yet have clear evidence. This study exists to measure whether this newer treatment actually does reduce brain injury risk.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will undergo the VARIPULSE ablation procedure for your irregular heartbeat as planned. Within 1–3 days after the procedure, you'll have a brain MRI scan to look for any tiny injuries, and you'll complete some simple memory and cognitive tests (like tests of your thinking, memory, and attention). After that, you'll receive standard follow-up care for your heart rhythm condition at the hospital.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
South Korea
Sponsor
Seoul National University Hospital
Collaborators
Biosense Webster, Inc.
Enrollment target
~40 participants
Started
December 2025
Primary completion
December 2027
Age range
19 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Eue-Keun Choi, MD, PhD
Seoul National University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.