Plain-English translation of NCT07364578 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether probiotic supplements—live, beneficial bacteria—can help reduce pain and stiffness in people with knee osteoarthritis. Researchers believe that probiotics might help by improving gut health and reducing inflammation in the body. Half of participants will receive standard arthritis care plus probiotic supplements twice daily, while the other half will receive standard care alone.
Right now, treatments for knee arthritis mainly focus on pain relief or trying to repair joint damage, but there's no cure. This trial is exploring whether this medication might work differently by supporting the body's natural defenses and reducing inflammation from within.
If you join this study, you'll be randomly assigned to either take probiotic supplements twice daily alongside your regular arthritis care, or to continue with standard care alone. The study will track your pain levels, knee function, and overall quality of life over the course of the trial. You'll likely have multiple visits to assess how the treatment is working and report any side effects.
AI-generated summary from trial data · Jun 21, 2026 · Not medical advice
Egypt
Phase
Large-scale testing
Sponsor
Beni-Suef University
Enrollment target
~146 participants
Started
February 2025
Primary completion
February 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.