Recruiting

Comparing Two Chemotherapy Combinations After Stomach Cancer Surgery

Plain-English translation of NCT07366528 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial compares two chemotherapy combinations used after stomach cancer surgery. One combination uses , and the other uses . The study is trying to determine if these two treatments work equally well, and which one might be easier for patients to tolerate based on side effects and treatment length.

Both of these medication combinations are currently recommended for stage 3 stomach cancer, but doctors have never directly compared them in the same study. This medication is being tested to help doctors understand which treatment is best for their patients — one that's easier to tolerate and stick with over time.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with adenocarcinoma (a type of cancer) of the stomach or the area where the stomach meets the esophagus
you have had stomach cancer surgery (D2 gastrectomy) with complete tumor removal and no prior chemotherapy
your cancer is stage 3 (IIIA, IIIB, or IIIC) with no signs of spread to distant parts of your body
your blood counts and organ function are healthy enough to handle chemotherapy
you are willing to use contraception if you are of childbearing age

You likely don't qualify if…

you have had another type of cancer before (except skin cancer or early cervical cancer that was cured)
you have serious health problems that would likely shorten your life to less than 5 years
you have uncontrolled infections or chronic diseases like unmanaged high blood pressure, diabetes, or heart disease
you are allergic to any of the study medications
you have bowel obstruction or other conditions that prevent you from taking pills by mouth

What participation looks like

If you join this trial, you will be randomly assigned to receive one of the two chemotherapy combinations. One group receives 8 cycles of oxaliplatin (given intravenously) combined with an oral pill called S-1 taken at home. The other group receives 6 cycles of docetaxel (intravenously) plus S-1, followed by S-1 alone for several more months. You'll visit the hospital regularly for chemotherapy infusions and blood tests, with the entire treatment lasting several months to about a year depending on which medication you receive.

AI-generated summary from trial data · Jun 16, 2026 · Not medical advice

Trial locations(5 sites)

China

Yuebei People's Hospital, Shaoguan, Guandong

Fudan University Shanghai Cancer Center, Shanghai

Renji Hospital, Shanghai

Ruijin Hospital, Shanghai

Shanghai Tenth People's Hospital, Shanghai