Testing a new injection for high blood pressure and high cholesterol

Plain-English translation of NCT07368608 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing BEBT-701, a new medication given by injection, to see if it can help lower blood pressure and LDL cholesterol (the 'bad' cholesterol). The study will first test different doses in a smaller group to make sure the medication is safe, then test the most promising doses in a larger group over several months to see how well it works.

Many people have high blood pressure and high cholesterol at the same time, and current treatments don't work well enough for everyone. This medication is being developed as a new option that might help control both conditions.

Do you qualify?

You likely qualify if…

you are between 18 and 60 years old
you have been diagnosed with high blood pressure (either never treated or off blood pressure medications for at least 30 days)
you have elevated LDL cholesterol (either never treated or off cholesterol medications for at least 30 days, depending on the study phase)
your body mass index is between 18.6 and 30 kg/m²
you are willing to use effective contraception and avoid pregnancy for 12 months after your last dose
you have maintained a stable diet for at least 4 weeks and plan to keep it that way during the study

You likely don't qualify if…

you have a history of heart failure, heart attack, stroke, or serious heart rhythm problems
you have a history of severe allergies (3 or more drug or food allergies) or known reactions to similar injectable medications
you have recently used (within 6–12 months) other experimental cholesterol or blood pressure medications that work similarly
you have had cancer in the past 5 years (except for certain skin cancers that were fully treated)
you have serious kidney, liver, blood, immune system, nerve, stomach, or mental health disorders that could affect the study

What participation looks like

The study has two phases. First, a smaller group will receive different doses of the medication (or placebo) as a single injection to test safety and find the best dose. Then, a larger group will receive injections of the selected doses (or placebo) over several weeks and be followed for up to 6 months or longer. You will have multiple clinic visits for blood pressure checks, blood tests, and to receive injections, and you may wear a blood pressure monitor at home to measure your blood pressure over 24 hours.

AI-generated summary from trial data · Aug 21, 2026 · Not medical advice

Trial locations(1 site)

China

The Third Xiangya Hospital of Central South University, Changsha, Hunan