How Bodies Handle Phosphate When Eating Different Amounts

Plain-English translation of NCT07368946 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This research study is testing how your body handles phosphate — a mineral found in food — when you eat increasing amounts of it over three weeks. Researchers want to understand whether people with chronic kidney disease (stages 3–4) respond differently to higher phosphate intake than people with healthy kidneys. By comparing blood and urine samples from both groups, the study team hopes to learn more about how kidneys affected by disease manage this mineral.

People with chronic kidney disease often struggle to regulate phosphate levels in their blood, which can lead to serious complications affecting bones and heart health. This study aims to better understand how much phosphate causes problems in people with kidney disease so doctors can give better dietary guidance in the future.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have chronic kidney disease at stage 3 or 4 (or you are healthy with normal kidney function, depending on which group you join)
you normally eat between 1,700 and 2,700 calories per day
you are able to store and prepare food at home using a refrigerator, freezer, microwave, or oven
you speak and read English

You likely don't qualify if…

you are pregnant, breastfeeding, or less than 3 months postpartum
you currently use dialysis or have received a kidney transplant
you smoke cigarettes, vape, or use nicotine or recreational drugs
you have a history of stroke or heart attack
you have conditions that affect how your body handles phosphate, such as thyroid disorder, parathyroid disorder, or inflammatory bowel disease
you are already taking phosphate binders or phosphate supplements
you have a food allergy to milk, eggs, soy, nuts, shellfish, wheat, gluten, or sodium phosphate, or follow restrictive diets like vegetarian, vegan, or ketogenic

What participation looks like

You will eat provided meals for 21 days while gradually increasing the amount of phosphate in your diet — starting at about 777 mg per day for the first week, then 1,277 mg the second week, and 1,777 mg the third week. All other nutrients (salt, potassium, and calcium) will stay the same throughout. You'll have blood drawn and provide urine samples at the start and end of each week to measure how your body is handling the phosphate.

AI-generated summary from trial data · Jun 21, 2026 · Not medical advice

How Bodies Handle Phosphate When Eating Different Amounts

What is this trial?

Do you qualify?

What participation looks like

Trial locations