Plain-English translation of NCT07369557 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether combining guided mindfulness practice with accelerated intermittent theta-burst stimulation (aiTBS)—a type of non-invasive brain stimulation therapy—can help treat major depression. You would receive the brain stimulation treatment as your standard medical care at the university hospital, and during the treatment period, you'd also practice guided mindfulness meditation daily using a smartphone app. The study wants to see if adding mindfulness makes the treatment work better and helps people feel relief from depression.
Depression is difficult to treat, and many people don't respond well to medications alone. This trial explores whether combining the brain stimulation with mindfulness training might boost the treatment's effects and help people feel better more quickly.
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You would come to the Medical University of South Carolina for the accelerated brain stimulation treatment over a 5-day period as your standard care. During those days and throughout the treatment, you would practice 10–15 minutes of guided mindfulness meditation daily using the Waking Up smartphone app. You would complete brief surveys about your mood and mindfulness at the start, at the end of the 5-day treatment period, and again at 4 weeks and 12 weeks after treatment ends. The entire study participation lasts about 12 weeks.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
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